The effect of Galleria mellonella hemolymph polypeptides on Legionella gormanii.

Anti-Legionella dumoffii Activity of Galleria mellonella Defensin and Apolipophorin III

The gram-negative bacterium Legionella dumoffii is, beside Legionella pneumophila, an etiological agent of Legionnaires' disease, an atypical form of pneumonia. The aim of this study was to determine the antimicrobial activity of Galleria mellonella defense polypeptides against L. dumoffii. The extract of immune hemolymph, containing a mixture of defense peptides and proteins, exhibited a do...

The effect of Galleria mellonella hemolymph polypeptides on human brain glioblastoma multiforme cell line – a preliminary study

Immunity of the greater wax moth Galleria mellonella.

Investigation of insect immune mechanisms provides important information concerning innate immunity, which in many aspects is conserved in animals. This is one of the reasons why insects serve as model organisms to study virulence mechanisms of human pathogens. From the evolutionary point of view, we also learn a lot about host-pathogen interaction and adaptation of organisms to conditions of l...

Differences in Virulence Between Legionella pneumophila Isolates From Human and Non-human Sources Determined in Galleria mellonella Infection Model

Citation: Sousa PS, Silva IN, Moreira LM, Veríssimo A and Costa J (2018) Differences in Virulence Between Legionella pneumophila Isolates From Human and Non-human Sources Determined in Galleria mellonella Infection Model. Front. Cell. Infect. Microbiol. 8:97. doi: 10.3389/fcimb.2018.00097 Differences in Virulence Between Legionella pneumophila Isolates From Human and Non-human Sources Determine...

Purification and characterization of eight peptides from Galleria mellonella immune hemolymph.

Defense peptides play a crucial role in insect innate immunity against invading pathogens. From the hemolymph of immune-challenged greater wax moth, Galleria mellonella (Gm) larvae, eight peptides were isolated and characterized. Purified Gm peptides differ considerably in amino acid sequences, isoelectric point values and antimicrobial activity spectrum. Five of them, Gm proline-rich peptide 2...